In his memoirs, Benjamin Franklin wrote of his psoriasis and his problems treating it late in life. He stopped taking pills a doctor had given him because his teeth were loosening and falling out. He found baths and sunlight helpful in controlling it, but never found a cure.
Now, 300 years after Franklin's birth, there's still no cure. Many treatments have harmful side effects. New protein-based injectable medicines can cost up to $25,000 annually, beyond the reach of many patients.